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Croatia is a net food importer with policies focused on increasing agricultural productivity. However, Croatia competitive advantage remains in marketing premium "natural" agricultural products and is opposed to full and open adoption of biotechnology foods. Croatia follows the European Union’s (EU) biotech legislation but has “opted-out” of planting genetically engineered (GE) seeds.

On October 1, 2019, El Salvador agreed to harmonize the biosafety technical regulation for “modified living organisms” for agricultural use with Guatemala and Honduras and designated the Ministry of Agriculture as the National Competent Authority to provide authorizations and keep registries related to biotechnology.